Updated phase 2 data showed a 60% ORR and 86% CNS ORR with frontline silevertinib in non-classical EGFR-mutant NSCLC; FDA discussion supported a phase 3 trial in 2027.
|Videos|October 22, 2013
Treating Advanced-Stage Lung Cancer with TKIs
Author(s)Paul A. Bunn, Jr, MD
Paul A. Bunn, Jr, MD, explains how patients with advanced-stage lung cancer benefit from tyrosine kinase inhibitors (TKIs)
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Paul A. Bunn, Jr, MD, professor of medicine in medical oncology, head of the division of medical oncology, University of Colorado, explains how patients with advanced-stage lung cancer benefit from tyrosine kinase inhibitors (TKIs)
Clinical Pearls
- Many patients have comorbid diseases and are very sick when they are diagnosed with lung cancer
- TKIs are oral, do not require an IV and they do not have grade 3 and 4 life-threatening toxicities
- Sick patients who have lung cancer should have molecular testing to see if they are eligible to use TKIs
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