GYNECOLOGIC CANCERS

General Cancer

A partial clinical hold has been placed on the phase III AIM2CERV trial by the FDA, Advaxis, Inc. has announced.¹ The trial is evaluating the use of the investigational immunotherapy agent axalimogene filolisbac in high-risk locally advanced cervical cancer.

Despite all the positive data associated with PARP inhibitors for the treatment of patients with&nbsp;epithelial ovarian cancer who have known <em>BRCA</em> mutations, these agents are not curing patients, said Leslie M. Randall, MD, MAS, at the 2019 SGO Annual Winter Meeting.

Women with recurrent or metastatic cervical cancer who fail prior treatment are known to have a poor prognosis, but immunotherapy may extend their survival, according to a presentation by Deanna Teoh, MD, MS, at the 2019 SGO Annual Winter Meeting.

Genomic testing can help physicians in the treatment decision process for women with ovarian cancer.&nbsp;As more of these platforms become commercially available, however, physicians must also learn the similarities and differences between each of these tests.

Debra Richardson, MD, discussed the role of PARP inhibitor combinations for frontline maintenance of women with ovarian cancer at the 2019 SGO Winter Meeting.

Findings of a recent study suggest HPV testing should be incorporated into cervical cancer screening programs. The&nbsp;nested case-control Swedish study&nbsp;found that the presence of&nbsp;specific subtypes of HPV, namely HPV-16 and -18, were associated&nbsp;with a higher risk of developing high-grade cervical intraepithelial neoplasia in women under the age of 30.

According to recently announced topline findings, the confirmatory phase III SOLO-3 trial of&nbsp;olaparib has met its primary endpoint, demonstrating a statistically significant and clinically meaningful improvement in&nbsp;objective response rate in patients with <em>BRCA</em>-mutant ovarian cancer who have relapsed on at least 2 prior lines of therapy

Danny Rischin, MD, MBBS, FRACP, discussed the results from a phase II trial looking at cemiplimab (Libtayo) in patients with advanced or recurrent cervical cancer.

At a planned interim analysis of the&nbsp;phase III JAVELIN Ovarian 100 study evaluating frontline avelumab in ovarian cancer, an independent panel determined the study would not meet its primary endpoint of progression-free survival. The co-developers of the PD-L1 inhibitor have announced they will terminate the trial on this basis.

Dasatinib (Sprycel) tablets has been approved by the FDA to be used in combination with chemotherapy for the treatment of pediatric patients &ge;1 year of age with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia.<br /> &nbsp;

Several oncology experts discuss the FDA approvals they found most significant in 2018.