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Opinion|Videos|January 15, 2025

Academic Perspectives for LR-MDS Treatment in the Community

Author(s)Guillermo Garcia-Manero, MD, David Swoboda, MD

Panelists discuss key learnings from recent studies on lower-risk myelodysplastic syndrome (LR-MDS) treatment, identify remaining knowledge gaps, and offer final takeaways, including their thoughts on the role of luspatercept in the evolving LR-MDS treatment landscape, clinical pearls for community oncologists, and major unanswered questions that could improve outcomes for LR-MDS and anemia management in the future.

Episodes in this series

EP. 1 Introduction to the Discussion of Frontline Treatment for Newly Diagnosed Lower-Risk Myelodysplastic Syndromes.

EP. 1 Introduction to the Discussion of Frontline Treatment for Newly Diagnosed Lower-Risk Myelodysplastic Syndromes.

EP. 2 Defining LR-MDS: Initial Patient Presentation and Updates in MDS Risk.

EP. 2 Defining LR-MDS: Initial Patient Presentation and Updates in MDS Risk.

EP. 3 Frontline Treatment Options for LR-MDS Beyond ESAs

EP. 3 Frontline Treatment Options for LR-MDS Beyond ESAs

EP. 4 Overview of Frontline Luspatercept in LR-MDS

EP. 4 Overview of Frontline Luspatercept in LR-MDS

EP. 5 Academic Perspectives: Patient Populations for Frontline Luspatercept in LR-MDS

EP. 5 Academic Perspectives: Patient Populations for Frontline Luspatercept in LR-MDS

EP. 6 Emerging Insights and Perspectives From COMMANDS (Luspatercept in LR-MDS)

EP. 6 Emerging Insights and Perspectives From COMMANDS (Luspatercept in LR-MDS)

EP. 7 The Impact of Mutational Burden on Responses With Frontline Luspatercept in LR-MDS

EP. 7 The Impact of Mutational Burden on Responses With Frontline Luspatercept in LR-MDS

EP. 8 Factors that Influence Treatment Choices and Goals in Frontline LR-MDS

EP. 8 Factors that Influence Treatment Choices and Goals in Frontline LR-MDS

EP. 9 Dosing Strategies for Frontline luspatercept in LR-MDS

EP. 9 Dosing Strategies for Frontline luspatercept in LR-MDS

EP. 10 Novel Updates in Second-line Therapies for LR-MDS

EP. 10 Novel Updates in Second-line Therapies for LR-MDS

EP. 11 Sequencing Therapies in LR-MDS

EP. 11 Sequencing Therapies in LR-MDS

EP. 12 Academic Perspectives for LR-MDS Treatment in the Community

EP. 12 Academic Perspectives for LR-MDS Treatment in the Community

Given all the treatment strategies and key updates discussed today, what are your overall thoughts on luspatercept in the LR-MDS treatment landscape?
What clinical pearls can you leave for community oncologists?
1. In your opinion, what are the major unanswered questions that could continue to improve outcomes for LR-MDS treatment and anemia management?
2. Please discuss any emerging concepts or other considerations that could influence treatment in the coming years.

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