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Opinion|Videos|December 25, 2024

Emerging Insights and Perspectives From COMMANDS (Luspatercept in LR-MDS)

Author(s)Guillermo Garcia-Manero, MD, David Swoboda, MD

Panelists discuss key takeaways from the COMMANDS trial, including the analysis of biomarkers in responders by ribosomal stress status (Hayati et al, EHA 2024), the impact of luspatercept on cell lineages (Garcia-Manero et al, EHA 2024), and the long-term clinical value of extended RBC transfusion independence (RBC-TI) (Garcia-Manero et al, ASH 2024).

Episodes in this series

EP. 1 Introduction to the Discussion of Frontline Treatment for Newly Diagnosed Lower-Risk Myelodysplastic Syndromes.

EP. 1 Introduction to the Discussion of Frontline Treatment for Newly Diagnosed Lower-Risk Myelodysplastic Syndromes.

EP. 2 Defining LR-MDS: Initial Patient Presentation and Updates in MDS Risk.

EP. 2 Defining LR-MDS: Initial Patient Presentation and Updates in MDS Risk.

EP. 3 Frontline Treatment Options for LR-MDS Beyond ESAs

EP. 3 Frontline Treatment Options for LR-MDS Beyond ESAs

EP. 4 Overview of Frontline Luspatercept in LR-MDS

EP. 4 Overview of Frontline Luspatercept in LR-MDS

EP. 5 Academic Perspectives: Patient Populations for Frontline Luspatercept in LR-MDS

EP. 5 Academic Perspectives: Patient Populations for Frontline Luspatercept in LR-MDS

EP. 6 Emerging Insights and Perspectives From COMMANDS (Luspatercept in LR-MDS)

EP. 6 Emerging Insights and Perspectives From COMMANDS (Luspatercept in LR-MDS)

EP. 7 The Impact of Mutational Burden on Responses With Frontline Luspatercept in LR-MDS

EP. 7 The Impact of Mutational Burden on Responses With Frontline Luspatercept in LR-MDS

EP. 8 Factors that Influence Treatment Choices and Goals in Frontline LR-MDS

EP. 8 Factors that Influence Treatment Choices and Goals in Frontline LR-MDS

EP. 9 Dosing Strategies for Frontline luspatercept in LR-MDS

EP. 9 Dosing Strategies for Frontline luspatercept in LR-MDS

EP. 10 Novel Updates in Second-line Therapies for LR-MDS

EP. 10 Novel Updates in Second-line Therapies for LR-MDS

EP. 11 Sequencing Therapies in LR-MDS

EP. 11 Sequencing Therapies in LR-MDS

EP. 12 Academic Perspectives for LR-MDS Treatment in the Community

EP. 12 Academic Perspectives for LR-MDS Treatment in the Community

Please briefly discuss these additional key takeaways from COMMANDS:
1. Analysis of biomarkers in responders by ribosomal stress status: Hayati et al, EHA 2024.
2. Impact of luspatercept on cell lineages: Garcia-Manero et al, EHA 2024.
3. Long term clinical value, extended RBC-TI: Garcia-Manero et al, ASH 2024

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