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Opinion|Videos|December 25, 2024

Academic Perspectives: Patient Populations for Frontline Luspatercept in LR-MDS

Panelists discuss how the final efficacy and safety analysis from the COMMANDS trial (Della Porta et al, Lancet 2024) highlights the role of luspatercept in first-line treatment for lower-risk myelodysplastic syndrome (LR-MDS), with particular consideration of ribosomal stress (RS) status and serum erythropoietin (EPO) levels, emphasizing its potential to improve hemoglobin levels and transfusion independence in this patient population.

Episodes in this series
  1. Discuss final efficacy and safety analysis from the COMMANDS trial (Della Porta et al, Lancet 2024).
    1. Elaborate on the role of luspatercept in first-line treatment of patients with LR-MDS
    2. Consider RS status and serum EPO level.
    3. What are your thoughts on the efficacy and potential benefits of luspatercept in this patient population?

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