LUNG CANCER

Jared Weiss, MD, led a discussion about a 59-year-old patient with RET-fusion-positive non–small cell lung cancer during a Targeted Oncology Case-Based Roundtable event.

Treatment with amivantamab-vmjw in the phase 1 CHRYSALIS study has released anti-tumor activity in patients with non-small cell lung cancer harboring MET exon 14 skipping mutations treated with the agent.

Jorge Nieva, MD, discusses the results of the Impower010 study, which evaluated the efficacy of the checkpoint inhibitor atezolizumab after chemotherapy for lung cancer compared to best supportive care. 

Joel Neal, MD, PhD, and Alexander I Spira, MD, PhD, FACP, review current treatments for EGFR Exon 20 Insertion+ NSCLC, their preferred treatments, and current clinical trials.

Experts review the demographics of patients who should be tested and how to discuss EGFR Exon 20 Insertion+ NSCLC with patients.

Molecular testing revealed RET-mutant non–small cell lung cancer in a 59-year-old patient. The case was a topic of discussion during a Case-Based Roundtable event led by Kartik Konduri, MD.

A discussion on how this variant of NSCLC differs from the (exon 19 and exon 21) EGFR mutations and the demographics of EGFR patients.

Joel Neal, MD, PhD, and Alexander I Spira, MD, PhD, FACP, discuss the recent identification of EGFR exon 20 insertion+ mNSCLC and how patients responded before the new drugs were introduced.

A significantly longer overall survival was achieved with the human IgG4 monoclonal antibody sintilimab in patients with locally advanced or metastatic nonsquamous non–small cell lung cancer treated in the phase 3 ORIENT-11 clinical trial.

Molecular testing practices and treatment decisions can vary for patients with non–small cell lung cancer. Cesar A. Perez, MD, and a group of other physicians discussed next steps in care for a patient with non–small cell lung cancer whose molecular test results revealed a RET mutation.

During a Targeted Oncology Case-Based Roundtable event, Harry Harper, MD, discussed treatment approaches for a 68-year-old patient with RET-mutated non–small cell lung cancer.

Patients with advanced non-small cell lung cancer treated with cemiplimab in combination with platinum-doublet chemotherapy saw an improvement in overall survival in comparison with patients who received chemotherapy alone, meeting the primary end point of the phase 3 EMPOWER-Lung 3 study.

In a Targeted Oncology Case-Based Roundtable event Edward S. Kim, MD, MBA, discussed new regimens for the treatment of non-small cell lung cancer.

The FDA has accepted the supplemental biologics license application submitted for atezolizumab as adjuvant treatment following surgery and platinum-based chemotherapy for people with non-small cell lung cancer whose tumors express PD-L1≥1%, as determined by an FDA-approved test and granted it priority review.

In an interview with Targeted Oncology™, Robert Coleman, MD, discussed the evolving treatment paradigm of lung cancer and the role of molecular testing now and in the future. 

In an interview with Targeted Oncology, Jorge A. Rios, MD, discusses recent advances in non–small cell lung cancer and the role targeted and immune checkpoint inhibitor therapy has played in this progress.

During a Targeted Oncology Case-Based Roundtable event, Jarushka Naidoo, MB, BCh, MHS. discussed the case of a 73-year-old patient with small cell lung cancer who first presented with shortness of breath, productive cough, chest pain, and fatigue.

Edward S. Kim, MD, MBA discusses immunotherapy-realted adverese events in non-small cell lung cancer in a rountable discussion with Albert Dekker, MD and Sam Yeh, MD.

Edward B. Garon, MD, MS leads a roundtable discussion on the impact of RET mutations on the lung cancer space.

During a Targeted Oncology Case-Based Roundtable event, Grace K. Dy, MD and 9 other physicians discussed molecular testing for patients with non–small cell lung cancer.

The FDA has granted an orphan drug designation to the anticancer drug paclitaxel-hyaluronic acid for the treatment of malignant mesothelioma.

According to a poll, the majority of physicians would wait for molecular testing on a patient metastatic lung adenocarcinoma. Then, upon diagnosis of RET-mutant non–small cell lung cancer, a group of oncologists explained how they would go about treatment for the patient.

Ronald J. Scheff, MD, reviews the molecular testing practices for non–small cell lung cancer and frontline treatment of patients with PD-L1-positive non–small cell lung cancer during a Case-Based Roundtable event.

Adjuvant treatment with atezolizumab led to a significant improvement in disease-free survival versus supportive care in patients with PD-L1–positive non–small cell lung cancer.

Eric Nadler, MD, MPP, discusses the real-world patient characteristics and treatment duration of the immunotherapy combination treatment studied in the IMpower133 trial in extensive-stage small cell lung cancer.