Panelists discuss how the updated SEQUOIA Arm C data demonstrate that zanubrutinib monotherapy achieves a remarkable 72% progression-free survival at 5 years for high-risk patients with deletion 17p, showing similar outcomes to TP53 wild-type patients and establishing continuous monotherapy as an excellent option for these highest-risk patients.
Panelists discuss how to select among available Bruton tyrosine kinase (BTK) inhibitor treatment regimens for continuous vs fixed-duration strategies. They weigh the benefits of oral-only regimens against combination therapies that include intravenous (IV) infusions, while acknowledging the limited retreatment data for newer oral doublets.
Panelists discuss how the treatment landscape for treatment-naive patients with chronic lymphocytic leukemia (CLL) is rapidly evolving with new guideline updates every 6 to 12 months. They categorize approaches into fixed-duration vs continuous treatment strategies while emphasizing the need to study different molecular subtypes of CLL separately in future clinical trials.
An expert discusses emerging real-world strategies for managing adverse effects of antibody-drug conjugates (ADCs) in metastatic triple-negative breast cancer (mTNBC), emphasizing the importance of patient education about toxicities such as alopecia while highlighting the potential of ADCs to improve progression-free survival and quality of life.
An expert discusses the importance of managing adverse effects of antibody-drug conjugates (ADCs) in metastatic triple-negative breast cancer (mTNBC), highlighting strategies such as prophylactic growth factor support and emerging genetic screening for UGT1A1 polymorphisms to personalize and optimize patient care.
John L. Marshall, MD, and Marwan G. Fakih, MD, discussed the landscape and sequencing of treatment for refractory colorectal cancer.
Katherine McDaniel, MD, discusses fertility preservation options for patients facing a cancer diagnosis and how the landscape has changed over the past two decades.
Jacob Sands, MD, discusses the inclusion of Dato-DXd into the treatment landscape of EGFR-mutant NSCLC.
An expert discusses the multifaceted nature of CAR T-cell therapy for relapsed/refractory (R/R) large B-cell lymphoma (LBCL), emphasizing the need for early multidisciplinary coordination to address clinical, logistical, financial, and psychosocial challenges, ensuring patients are supported throughout the complex treatment journey.
An expert discusses the evolving management of relapsed/refractory (R/R) large B-cell lymphoma (LBCL), illustrating how CAR T-cell therapy has transformed third-line treatment from palliative to potentially curative, and emphasizing the importance of timely referral, reassessing eligibility, and individualizing care to optimize patient outcomes.
John Burke, MD, discusses his editor-in-chief column from the July 2025 issue of Targeted Therapies in Oncology.
John M. Burke, MD, discusses the FDA ODAC's decision on the use of daratumumab in high-risk smoldering multiple myeloma and its implications for clinical practice.
Unpredictable FDA and funding woes delay crucial drug approvals, depriving thousands of patients access to vital treatments for diseases like colon cancer.
Benjamin Schlechter, MD, discusses the safety and efficacy findings from the C-800-01 phase 1 trial evaluating botensilimab and balstilimab in colorectal cancer.
An expert discusses how optimal sequencing of therapies remains unclear in lower-risk MDS, with emerging combination strategies and ongoing trials that may help define the best treatment approaches.
An expert discusses how real-world evidence and patient-reported outcomes support luspatercept’s clinical benefits, while highlighting the high failure rates of ESA therapy in community practice.
Botensilimab/balstilimab (BOT/BAL) synergistically activate and sustain immune attack, offering a promising new strategy for various cancers.
Panelists discuss how implementing combination immunotherapy in clinical practice faces institutional barriers, including formulary approval for retifanlimab and payer authorization challenges. They maintain that published dosing schedules should be followed rather than modifying treatment intervals to address patient access barriers.
Panelists discuss how biomarker development in anal cancer remains limited with PD-L1 status not influencing treatment decisions, although rare targets like HER2, PIK3CA aberrations, and RAS wild-type status for EGFR inhibitors may warrant next-generation sequencing testing for research purposes, while emphasizing honest discussions about palliative treatment goals and quality-of-life balance.
An expert discusses that while CAR T-cell therapy has transformed the treatment landscape for primary refractory diffuse large B-cell lymphoma by outperforming traditional transplant approaches in the second-line setting, timely referral to specialized centers is critical, as misjudged eligibility and nonclinical barriers like geography, caregiver support, and insurance can delay or prevent access to this potentially curative therapy—challenges best addressed through proactive, multidisciplinary coordination.
An expert discusses that this case of a 60-year-old man with primary refractory diffuse large B-cell lymphoma highlights the urgent need for a shift in therapeutic strategy following early relapse after R-CHOP, with CAR T-cell therapy emerging as a preferred option given the poor prognosis of chemo-refractory disease, the patient’s eligibility for intensive treatment, and the critical role of timely referral, coordinated care, and transparent communication to optimize outcomes in high-risk lymphoma.
Benjamin Schlechter, MD, discusses the unmet needs and treatment gaps for patients with colorectal cancer.
Arturo Loaiza-Bonilla, MD, MSEd, discusses the significant advancements and ongoing efforts in integrating artificial intelligence into oncology.
Michael Caligiuri, MD, discusses the modulation of natural killer cells to enhance their ability to detect and destroy tumor cells.
An expert discusses the importance of timely biomarker testing and emerging challenges in treatment sequencing for metastatic triple-negative breast cancer (mTNBC), as first-line use of antibody-drug conjugates (ADCs) raises concerns about cross-resistance and the need for strategic postprogression planning.
An expert discusses the evolving role of biomarker testing in first-line metastatic triple-negative breast cancer (mTNBC), highlighting how PD-L1, BRCA status, and emerging markers such as Trop-2 expression are shaping personalized treatment approaches and guiding the integration of antibody-drug conjugates (ADCs) and immunotherapy.
Pedro C. Barata, MD, MSc, discusses the advantages and disadvantages of darolutamide in metastatic hormone-sensitive prostate cancer.
Rajshekhar Chakraborty, MD, discusses the safety and tolerability of linvoseltamab with carfilzomib when used for the treatment of patients with relapsed/refractory multiple myeloma.
Alicia Morgans, MD, MPH, covers what sets darolutamide apart from other androgen receptor inhibitors.