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Opinion|Videos|March 18, 2025

An Overview of Treatment Approaches for BPDCN

Author(s)Marlise R. Luskin, MD, MSCE

An expert discusses how, historically, blastic plasmacytoid dendritic cell neoplasm (BPDCN) was treated with regimens for acute leukemia or lymphoma. Current NCCN guidelines recommend intensive multiagent chemotherapy followed by allogeneic stem cell transplantation, when possible, with targeted therapies like tagraxofusp now available for specific cases.

Episodes in this series

1 expert in this video

EP. 1 A 62-Year-Old Man Who Is Newly Diagnosed With BPDCN

1 expert in this video

EP. 2 Understanding BPDCN: From Disease Presentation to Diagnosis

1 expert in this video

EP. 3 An Overview of Treatment Approaches for BPDCN

1 expert in this video

EP. 4 The Role of CD123 Targeted Therapy (tagraxofusp) in the Evolving Treatment Landscape for BPDCN

1 expert in this video

EP. 5 Academic Perspectives on Treatment Decisions for BPDCN

1 expert in this video

EP. 6 Adverse Events Monitoring and Management in BPDCN Treatment

1 expert in this video

EP. 7 Treatment Implementation and Long-Term Considerations in BPDCN

Video content above is prompted by the following:

Briefly, what have patients historically been treated with when diagnosed with BPDCN?
Please provide an overview of the current treatment options per NCCN guidelines.

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