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Opinion|Videos|March 18, 2025

The Role of CD123 Targeted Therapy (tagraxofusp) in the Evolving Treatment Landscape for BPDCN

Author(s)Marlise R. Luskin, MD, MSCE

An expert discusses how medical professionals have integrated tagraxofusp into blastic plasmacytoid dendritic cell neoplasm (BPDCN) treatment, leveraging its CD123-targeted efficacy per 0114 trial data. Real-world findings (Angelucci et al, ASH 2023) align with clinical outcomes, reinforcing tagraxofusp’s role in BPDCN management by supporting its safety and effectiveness in broader settings.

Episodes in this series

1 expert in this video

EP. 1 A 62-Year-Old Man Who Is Newly Diagnosed With BPDCN

1 expert in this video

EP. 2 Understanding BPDCN: From Disease Presentation to Diagnosis

1 expert in this video

EP. 3 An Overview of Treatment Approaches for BPDCN

1 expert in this video

EP. 4 The Role of CD123 Targeted Therapy (tagraxofusp) in the Evolving Treatment Landscape for BPDCN

1 expert in this video

EP. 5 Academic Perspectives on Treatment Decisions for BPDCN

1 expert in this video

EP. 6 Adverse Events Monitoring and Management in BPDCN Treatment

1 expert in this video

EP. 7 Treatment Implementation and Long-Term Considerations in BPDCN

Video content above is prompted by the following:

Given the efficacy/safety data from the 0114-trial evaluating tagraxofusp in BPDCN, how have you adapted your treatment approach to incorporate CD123 targeted therapy?
Do real-world data (Angelucci et al, ASH 2023) of tagraxofusp in BPDCN complement trial data?

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