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Opinion|Videos|March 19, 2025

Current and Emerging Uses of ctDNA in the Adjuvant MIUC Setting

Author(s)Matthew Galsky, MD

An expert discusses how medical professionals are increasingly utilizing circulating tumor DNA (ctDNA) and tissue PD-L1 to guide recommendations for adjuvant immune checkpoint inhibitor (ICI) therapy. ctDNA helps monitor minimal residual disease and early treatment response while tissue PD-L1 status aids in predicting ICI efficacy, optimizing patient treatment plans.

Episodes in this series

1 expert in this video

EP. 1 MIUC: Risk of Recurrence After Radical Cystectomy

1 expert in this video

EP. 2 High-Risk MIBC: Adjuvant Therapy Options After Radical Cystectomy

1 expert in this video

EP. 3 Phase 3 CheckMate 274 Study: Adjuvant Nivolumab for High-Risk MIUC—Aims and Design

1 expert in this video

EP. 4 Phase 3 CheckMate 274 Study: Adjuvant Nivolumab for High-Risk MIUC—Updated Results

1 expert in this video

EP. 5 Dr. Galsky’s Perspectives on the CheckMate 274 Data Results

1 expert in this video

EP. 6 Adjuvant Anti–PD-1 Decision-Making: PD-L1 Expression, Residual Disease, and Variant Histologies

1 expert in this video

EP. 7 Current and Emerging Uses of ctDNA in the Adjuvant MIUC Setting

1 expert in this video

EP. 8 Adjuvant ICI for High-Risk MIUC: AE Monitoring and Management

1 expert in this video

EP. 9 Adjuvant ICI for High-Risk MIUC: Patient Counseling

1 expert in this video

EP. 10 Dr. Galsky’s Perspectives on Subcutaneous ICI Dosing

Video content above is prompted by the following:

Are you using ctDNA and/or tissue PD-L1 to guide recommendations for adjuvant ICI and/or to monitor response to adjuvant ICI?

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