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Opinion|Videos|March 12, 2025

MIUC: Risk of Recurrence After Radical Cystectomy

An expert discusses how patients with muscle-invasive urothelial carcinoma (MIUC) undergoing radical cystectomy face a significant recurrence risk. High-risk factors include advanced stage, lymph node involvement, and positive surgical margins. Neoadjuvant cisplatin-based chemotherapy can improve survival but does not eliminate recurrence risk. Other predictors include lymphovascular invasion, variant histology, and systemic inflammation markers.

Episodes in this series

Video content above is prompted by the following:

  • What is the risk of recurrence for patients with muscle-invasive urothelial carcinoma who undergo radical cystectomy with or without neoadjuvant cisplatin-based chemotherapy? (Renner 2021; Kim 2015; Bellmunt 2022)
  • What factors put patients at higher risk for recurrence?

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