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Opinion|Videos|March 12, 2025

MIUC: Risk of Recurrence After Radical Cystectomy

Author(s)Matthew Galsky, MD

An expert discusses how patients with muscle-invasive urothelial carcinoma (MIUC) undergoing radical cystectomy face a significant recurrence risk. High-risk factors include advanced stage, lymph node involvement, and positive surgical margins. Neoadjuvant cisplatin-based chemotherapy can improve survival but does not eliminate recurrence risk. Other predictors include lymphovascular invasion, variant histology, and systemic inflammation markers.

Episodes in this series

1 expert in this video

EP. 1 MIUC: Risk of Recurrence After Radical Cystectomy

1 expert in this video

EP. 2 High-Risk MIBC: Adjuvant Therapy Options After Radical Cystectomy

1 expert in this video

EP. 3 Phase 3 CheckMate 274 Study: Adjuvant Nivolumab for High-Risk MIUC—Aims and Design

1 expert in this video

EP. 4 Phase 3 CheckMate 274 Study: Adjuvant Nivolumab for High-Risk MIUC—Updated Results

1 expert in this video

EP. 5 Dr. Galsky’s Perspectives on the CheckMate 274 Data Results

1 expert in this video

EP. 6 Adjuvant Anti–PD-1 Decision-Making: PD-L1 Expression, Residual Disease, and Variant Histologies

1 expert in this video

EP. 7 Current and Emerging Uses of ctDNA in the Adjuvant MIUC Setting

1 expert in this video

EP. 8 Adjuvant ICI for High-Risk MIUC: AE Monitoring and Management

1 expert in this video

EP. 9 Adjuvant ICI for High-Risk MIUC: Patient Counseling

1 expert in this video

EP. 10 Dr. Galsky’s Perspectives on Subcutaneous ICI Dosing

Video content above is prompted by the following:

What is the risk of recurrence for patients with muscle-invasive urothelial carcinoma who undergo radical cystectomy with or without neoadjuvant cisplatin-based chemotherapy? (Renner 2021; Kim 2015; Bellmunt 2022)
What factors put patients at higher risk for recurrence?

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