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Opinion|Videos|March 13, 2025

Dr. Galsky’s Perspectives on the CheckMate 274 Data Results

Author(s)Matthew Galsky, MD

An expert discusses how recent data on adjuvant anti–PD-1 trials highlight the significance of disease-free survival (DFS) and overall survival (OS), guiding clinical decisions. In muscle-invasive urothelial carcinoma (MIBC), event-free survival (EFS) and OS benefits without delaying curative cystectomy are crucial. Adjuvant nivolumab is typically initiated within 12 weeks post cystectomy, considering pathology, recovery, and performance status.

Episodes in this series

1 expert in this video

EP. 1 MIUC: Risk of Recurrence After Radical Cystectomy

1 expert in this video

EP. 2 High-Risk MIBC: Adjuvant Therapy Options After Radical Cystectomy

1 expert in this video

EP. 3 Phase 3 CheckMate 274 Study: Adjuvant Nivolumab for High-Risk MIUC—Aims and Design

1 expert in this video

EP. 4 Phase 3 CheckMate 274 Study: Adjuvant Nivolumab for High-Risk MIUC—Updated Results

1 expert in this video

EP. 5 Dr. Galsky’s Perspectives on the CheckMate 274 Data Results

1 expert in this video

EP. 6 Adjuvant Anti–PD-1 Decision-Making: PD-L1 Expression, Residual Disease, and Variant Histologies

1 expert in this video

EP. 7 Current and Emerging Uses of ctDNA in the Adjuvant MIUC Setting

1 expert in this video

EP. 8 Adjuvant ICI for High-Risk MIUC: AE Monitoring and Management

1 expert in this video

EP. 9 Adjuvant ICI for High-Risk MIUC: Patient Counseling

1 expert in this video

EP. 10 Dr. Galsky’s Perspectives on Subcutaneous ICI Dosing

Video content above is prompted by the following:

What are your perspectives on the data, and what has been learned? How are you applying these results to your practice?
To what degree do you consider the benefit regarding DFS vs OS in adjuvant anti–PD-1 trials?
What is the importance of EFS and OS benefit with no associated delay in curative intent radical cystectomy for your patients with MIBC?
What is the time window in patients after radical cystectomy prior to initiating adjuvant nivolumab (if no metastases)? Which factors inform your decision?

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