
Opinion|Videos|May 19, 2026
KOL Experience and Next Steps With Zongertinib in HER2-Positive
Author(s)Joshua K. Sabari, MD
Weight-based zanjohber niv dosing guide: adjust for CYP3A inhibitors and use early liver tests to avoid dose reductions.
Advertisement
Episodes in this series

Joshua K. Sabari, MD, discusses his personal experience treating patients with zongertinib as part of the Beamion LUNG‑1 trial, which supported the FDA approvals of zongertinib in patients with HER2 mutation–positive non–small cell lung cancer (NSCLC). He also highlights the ongoing confirmatory phase 3 Beamion LUNG-2trial (NCT06151574) comparing zongertinib with standard of care in frontline HER2-positive NSCLC.
Advertisement
Related to this article

FDA expands pirtobrutinib into first-line CLL/SLL for adults without 17p deletion, delivering major PFS gains versus bendamustine-rituximab.

Submission of a new drug application for zipalertinib plus chemotherapy has begun under the FDA's RTOR program, based on phase 3 REZILIENT3 data showing a 6-month PFS gain.

Insurance hurdles and steep out-of-pocket costs often delay or prevent patients from filling specialty oral blood cancer drugs, even after eventual approvals.

Telehealth transplant consults help patients with multiple myeloma overcome racial, age, and rural barriers, speeding eligibility screening and expanding access to specialists.

The MUC16xCD3 bispecific antibody showed a 73% response rate in phase 1/2 trial; the sponsor announced plans for a potential registrational cohort and phase 3 trial.

Five myeloma experts share their top takeaways from IMS 2026, including the CERVINO trial and long-term follow-up from the PERSEUS study.

Giredestrant plus everolimus reduced the risk of progression or death by 44% in the ITT population and 62% in ESR1-mutated disease in phase 3 evERA data published in NEJM.
Advertisement
Advertisement
Trending on Targeted Oncology - Immunotherapy, Biomarkers, and Cancer Pathways
1
Ubamatamab Shows Durable Responses in Low-Grade Serous Ovarian Cancer
2
Pirtobrutinib Gains FDA Approval for Frontline CLL/SLL in Select Patients
3
What Stood Out at IMS 2026? Five Myeloma Experts Weigh In
4
New Drug Application Filed for Savolitinib/Osimertinib in MET+ NSCLC
5

