Opinion|Videos|May 19, 2026

KOL Experience and Next Steps With Zongertinib in HER2-Positive

Author(s)Joshua K. Sabari, MD

Weight-based zanjohber niv dosing guide: adjust for CYP3A inhibitors and use early liver tests to avoid dose reductions.

Episodes in this series

EP. 1 Background of Targeting HER2 in NSCLC

EP. 1 Background of Targeting HER2 in NSCLC

EP. 2 Emerging Treatment Options for HER2-Positive NSCLC

EP. 2 Emerging Treatment Options for HER2-Positive NSCLC

EP. 3 Beamion LUNG‑1 Trial: Zongertinib in HER2-Positive NSCLC

EP. 3 Beamion LUNG‑1 Trial: Zongertinib in HER2-Positive NSCLC

EP. 4 Depth and Durability of Response to Zongertinib in HER2-Positive NSCLC

EP. 4 Depth and Durability of Response to Zongertinib in HER2-Positive NSCLC

EP. 5 Safety and Tolerability of Zongertinib in HER2-Positive NSCLC

EP. 5 Safety and Tolerability of Zongertinib in HER2-Positive NSCLC

EP. 6 Next-Generation Sequencing and HER2-Mutations in Metastatic NSCLC

EP. 6 Next-Generation Sequencing and HER2-Mutations in Metastatic NSCLC

EP. 7 Optimizing Administration of Zongertinib in HER2-Positive NSCLC

EP. 7 Optimizing Administration of Zongertinib in HER2-Positive NSCLC

EP. 8 KOL Experience and Next Steps With Zongertinib in HER2-Positive

EP. 8 KOL Experience and Next Steps With Zongertinib in HER2-Positive

EP. 9 Ongoing Research With Zongertinib in NSCLC

EP. 9 Ongoing Research With Zongertinib in NSCLC

Joshua K. Sabari, MD, discusses his personal experience treating patients with zongertinib as part of the Beamion LUNG‑1 trial, which supported the FDA approvals of zongertinib in patients with HER2 mutation–positive non–small cell lung cancer (NSCLC). He also highlights the ongoing confirmatory phase 3 Beamion LUNG-2trial (NCT06151574) comparing zongertinib with standard of care in frontline HER2-positive NSCLC.

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