Opinion|Videos|May 12, 2026

Next-Generation Sequencing and HER2-Mutations in Metastatic NSCLC

Author(s)Joshua K. Sabari, MD

Zongertinib shows strong tolerability in frontline lung cancer cohort, with mostly mild diarrhea, minimal rash, low ILD, and few dose stops.

Episodes in this series

EP. 1 Background of Targeting HER2 in NSCLC

EP. 1 Background of Targeting HER2 in NSCLC

EP. 2 Emerging Treatment Options for HER2-Positive NSCLC

EP. 2 Emerging Treatment Options for HER2-Positive NSCLC

EP. 3 Beamion LUNG‑1 Trial: Zongertinib in HER2-Positive NSCLC

EP. 3 Beamion LUNG‑1 Trial: Zongertinib in HER2-Positive NSCLC

EP. 4 Depth and Durability of Response to Zongertinib in HER2-Positive NSCLC

EP. 4 Depth and Durability of Response to Zongertinib in HER2-Positive NSCLC

EP. 5 Safety and Tolerability of Zongertinib in HER2-Positive NSCLC

EP. 5 Safety and Tolerability of Zongertinib in HER2-Positive NSCLC

EP. 6 Next-Generation Sequencing and HER2-Mutations in Metastatic NSCLC

EP. 6 Next-Generation Sequencing and HER2-Mutations in Metastatic NSCLC

EP. 7 Optimizing Administration of Zongertinib in HER2-Positive NSCLC

EP. 7 Optimizing Administration of Zongertinib in HER2-Positive NSCLC

EP. 8 KOL Experience and Next Steps With Zongertinib in HER2-Positive

EP. 8 KOL Experience and Next Steps With Zongertinib in HER2-Positive

EP. 9 Ongoing Research With Zongertinib in NSCLC

EP. 9 Ongoing Research With Zongertinib in NSCLC

Joshua K. Sabari, MD, explains that it is critical for all patients with metastatic non–small cell lung cancer, regardless of clinical characteristics, to obtain broad panel next-generation sequencing (NGS). He then shares his expert insight on HER2 alterations that may be identified by NGS.

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