Opinion|Videos|May 19, 2026

Ongoing Research With Zongertinib in NSCLC

Author(s)Joshua K. Sabari, MD

Zongertinib shows strong tolerance and 70%+ responses in HER2-mutant metastatic NSCLC, with a pivotal Phase III trial versus standard chemo-immunotherapy underway.

Episodes in this series

EP. 1 Background of Targeting HER2 in NSCLC

EP. 1 Background of Targeting HER2 in NSCLC

EP. 2 Emerging Treatment Options for HER2-Positive NSCLC

EP. 2 Emerging Treatment Options for HER2-Positive NSCLC

EP. 3 Beamion LUNG‑1 Trial: Zongertinib in HER2-Positive NSCLC

EP. 3 Beamion LUNG‑1 Trial: Zongertinib in HER2-Positive NSCLC

EP. 4 Depth and Durability of Response to Zongertinib in HER2-Positive NSCLC

EP. 4 Depth and Durability of Response to Zongertinib in HER2-Positive NSCLC

EP. 5 Safety and Tolerability of Zongertinib in HER2-Positive NSCLC

EP. 5 Safety and Tolerability of Zongertinib in HER2-Positive NSCLC

EP. 6 Next-Generation Sequencing and HER2-Mutations in Metastatic NSCLC

EP. 6 Next-Generation Sequencing and HER2-Mutations in Metastatic NSCLC

EP. 7 Optimizing Administration of Zongertinib in HER2-Positive NSCLC

EP. 7 Optimizing Administration of Zongertinib in HER2-Positive NSCLC

EP. 8 KOL Experience and Next Steps With Zongertinib in HER2-Positive

EP. 8 KOL Experience and Next Steps With Zongertinib in HER2-Positive

EP. 9 Ongoing Research With Zongertinib in NSCLC

EP. 9 Ongoing Research With Zongertinib in NSCLC

Joshua K. Sabari, MD, discusses exploring combination approaches as the next research step with zongertinib in patients with HER2 mutation–positive non–small cell lung cancer. He also discusses how ongoing research is specifically examining the role of zongertinib in patients with HER2 amplification and HER2 overexpression.

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