Opinion|Videos|April 28, 2026
Emerging Treatment Options for HER2-Positive NSCLC
Author(s)Joshua K. Sabari, MD
New FDA-approved zongepanib boosts responses in HER2-mutant lung cancer, delivering durable control with fewer side effects than standard chemo.
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Joshua K. Sabari, MD, discusses the standard approaches that have been used historically for treating patients with HER2‑mutant non–small cell lung cancer (NSCLC). These treatments have included chemotherapy alone as well as combination chemotherapy and immunotherapy. According to Sabari, emerging HER2-targeted agents, such as zongertinib, are showing improved efficacy and tolerability vs standard care.
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