Opinion|Videos|May 19, 2026

Optimizing Administration of Zongertinib in HER2-Positive NSCLC

Author(s)Joshua K. Sabari, MD

Broad NGS guides metastatic NSCLC care, spotlights common HER2/ERBB2 variants, and explains when liquid biopsy falls short for targeted therapy.

Episodes in this series

EP. 1 Background of Targeting HER2 in NSCLC

EP. 1 Background of Targeting HER2 in NSCLC

EP. 2 Emerging Treatment Options for HER2-Positive NSCLC

EP. 2 Emerging Treatment Options for HER2-Positive NSCLC

EP. 3 Beamion LUNG‑1 Trial: Zongertinib in HER2-Positive NSCLC

EP. 3 Beamion LUNG‑1 Trial: Zongertinib in HER2-Positive NSCLC

EP. 4 Depth and Durability of Response to Zongertinib in HER2-Positive NSCLC

EP. 4 Depth and Durability of Response to Zongertinib in HER2-Positive NSCLC

EP. 5 Safety and Tolerability of Zongertinib in HER2-Positive NSCLC

EP. 5 Safety and Tolerability of Zongertinib in HER2-Positive NSCLC

EP. 6 Next-Generation Sequencing and HER2-Mutations in Metastatic NSCLC

EP. 6 Next-Generation Sequencing and HER2-Mutations in Metastatic NSCLC

EP. 7 Optimizing Administration of Zongertinib in HER2-Positive NSCLC

EP. 7 Optimizing Administration of Zongertinib in HER2-Positive NSCLC

EP. 8 KOL Experience and Next Steps With Zongertinib in HER2-Positive

EP. 8 KOL Experience and Next Steps With Zongertinib in HER2-Positive

EP. 9 Ongoing Research With Zongertinib in NSCLC

EP. 9 Ongoing Research With Zongertinib in NSCLC

Joshua K. Sabari, MD, discusses dosing, administration, and optimal patient management when using zongertinib to treat patients with HER2 mutation–positive non–small cell lung cancer. He describes the standard weight-based dosing of the treatment as well as the adverse events to monitor early on to ensure optimal administration of zongertinib.

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