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Raymond Wadlow, MD, discusses interesting data presented for hepatocellular carcinoma at the 2018 Gastrointestinal Cancers Symposium.

Ahmed Omar Kaseb, MD, discusses the role of immunotherapy in the treatment landscape of HCC and the impact it could have in the presurgical setting.

Achieving an objective response to TKI therapy was associated with longer overall survival in patients with previously untreated hepatocellular carcinoma, according to findings of a retrospective analysis presented during the 2019 Gastrointestinal Cancers Symposium.

Cabozantinib has been approved by the FDA for the treatment of patients with hepatocellular carcinoma who previously received sorafenib, Exelixis, the company developing the agent, announced today.





Unresectable HCC with a History of Hepatitis C Virus

Kabir Mody, MD, discusses the importance of understanding sequencing in patients with hepatocellular carcinoma.

Kevin Staveley-O’Carroll, MD, PhD, discusses how the field of HCC has advanced over the last few years and how a mouse model at the University of Missouri is being used to further investigate immunotherapy treatment options.<br />

Michael J. Pishvaian, MD, PhD, discusses the potential for atezolizumab and bevacizumab in the frontline setting of HCC, as well the overall impact of immunotherapy in the treatment landscape of HCC.

A large pivotal phase III trial has been initiated to evaluate the potential for the first-line combination of cabozantinib and atezolizumab in comparison with standard-of-care sorafenib for patients with advanced hepatocellular carcinoma. Exelixis and Ipsen, the companies developing cabozantinib, announced the COSMIC-312 trial last week.






Unresectable HCC with Extrahepatic Involvement

Results from the phase I/II CheckMate 040 study demonstrated that single-agent nivolumab showed promising clinical activity in patients with Child-Pugh B advanced hepatocellular carcinoma, a population often excluded from advanced HCC trials.

Ghassan Abou-Alfa, MD, discusses the approved agents available for the treatment of hepatocellular carcinoma. Compared to 2007 when there was only 1 agent available, sorafenib, there is now a great number of options for these patients.

Pembrolizumab (Keytruda) has received an accelerated approval from the FDA for the treatment of patients with hepatocellular carcinoma who have previously received sorafenib (Nexavar).

Combining atezolizumab (Tecentriq) with bevacizumab (Avastin) induced promising and durable antitumor activity in patients with advanced hepatocellular carcinoma, according to findings from a phase Ib study presented during the 2018 ESMO Congress.

Kabir Mody, MD, discusses the evolution of the hepatocellular carcinoma treatment landscape over the past year during a presentation at the 2018 International Society of Gastrointestinal Oncology.

James L. Wade III, MD, FACP, FASCO, discusses the importance of clinical trials in the community.

















































