April 28th 2024
During a live Community Case Forum event in partnership with the Tennessee Oncology Practice Society, Pierre Gholam, MD, examined the current state of treatment for patients with hepatocellular carcinoma, looking in particular at what data is available for those with Child-Pugh B and C status who have poorer outcomes and have limited data from prospective clinical trials.
Community Practice Connections™: Real-World Applications of Novel Therapies Across TNBC and Addressing Disparities in Care
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6th Annual Precision Medicine Symposium: An Illustrated Tumor Board
October 18-19, 2024
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Advances in TNBC: Communicating with Your Patients About Clinical Trial Awareness and Treatment Concerns to Improve Clinical Outcomes
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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41st Annual CFS®: Innovative Cancer Therapy for Tomorrow
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Study Results Show Multidisciplinary Tumor Boards Lead to Improved OS for HCC Patients
December 27th 2016Multidisciplinary tumor boards led to higher utilization of guideline-recommended curative therapies, which was associated with improved overall survival (OS) for patients with early-stage hepatocellular carcinoma.
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The Possibility for Immunotherapy in Liver Cancer
December 15th 2016Tim F. Greten, MD, senior investigator, Thoracic and Gastrointestinal Oncology Branch, and head, Gastrointestinal Malignancy Section, National Cancer Institute Center for Cancer Research, discusses the possibility for immunotherapy in liver cancer.
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Regorafenib Demonstrates Survival Benefit in Second-Line Setting for Advanced HCC
December 7th 2016Regorafenib (Stivarga) demonstrates the first survival benefit in second-line setting for patients with hepatocellular carcinoma (HCC) who have progressed on sorafenib, according to results of the phase III RESORCE trial published in <em>The Lancet</em>.
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Early Support for Immunotherapy/Standard Therapy Combos in HCC
November 8th 2016Early evidence suggests that the combination of locoregional therapy with an immune checkpoint inhibitor is a safe and effective strategy to pursue for patients with advanced hepatocellular carcinoma (HCC), according to a leading liver immunology expert.
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Future Treatment Options for Advanced HCC Widening
November 8th 2016Regorafenib has emerged as the clear choice for second-line therapy in advanced hepatocellular carcinoma (HCC) after demonstrating survival improvements for patients whose disease has progressed after systemic treatment, according to liver cancer experts.
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Regorafenib Submitted to FDA for Approval in Advanced Liver Cancer
November 8th 2016A supplemental new drug application (sNDA) for the use of regorafenib (Stivarga) as a second-line treatment for patients with unresectable hepatocellular carcinoma (HCC) has been submitted to the FDA for approval.
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High Rates of Overall Survival Show Benefit of SBRT in Unresectable Liver Cancer
October 14th 2016Results from a phase II study from Korea demonstrated high rates of tumor local control, overall survival (OS), and grade 1/2 gastrointestinal and hepatic toxicities in patients who received stereotactic body radiotherapy (SBRT) for unresectable hepatocellular carcinoma (HCC) after incomplete transarterial chemoembolization (TACE).
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Regorafenib Has Potential to Become Second-Line Standard of Care in HCC
October 8th 2016The oral multikinase inhibitor regorafenib (Stivarga) has the potential to become the standard of care as second-line treatment in patients with previously treated hepatocellular carcinoma (HCC) who are unsuitable for loco-regional therapy and have progressed on sorafenib.
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Experts Debate Merits of Competing HCC Treatment Techniques
October 4th 2016Two competing methods of delivering locoregional therapy to patients with hepatocellular carcinoma (HCC) both have advantages and may be most successful in subgroups of individuals with intermediate-stage disease, according to experts who debated the relative merits of the techniques at the 2016 International Liver Cancer Association (ILCA) conference.
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Regorafenib Moves Ahead in Advanced HCC
September 19th 2016After 9 years of failed trials for once-promising drugs, regorafenib (Stivarga) has emerged as the clear choice for second-line therapy in advanced hepatocellular carcinoma (HCC) after demonstrating survival improvements for patients whose disease has progressed after systemic treatment, according to liver cancer experts.
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Nivolumab Maintains Positive Results in Latest HCC Findings
September 19th 2016Nivolumab (Opdivo) continues to post “highly encouraging’” and durable responses in patients with advanced hepatocellular carcinoma (HCC) regardless of whether they had hepatitis B or C or whether they had received prior treatment with sorafenib (Nexavar), according to the lead investigator on the early-phase study.
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Despite Growing Evidence for SBRT, the Jury Is Still Out
September 19th 2016The jury is still out on whether stereotactic body radiation therapy (SBRT) should truly be considered a preferred frontline treatment modality for patients with hepatocellular carcinoma (HCC) who are not candidates for surgery, despite an ever-growing body of evidence supporting this approach.
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New Evidence Supports a Key Role of the Immune System in HCC
September 19th 2016The immune system performs a complex role in the development and growth of hepatocellular carcinoma (HCC), according to evidence from preclinical and clinical studies that are beginning to unravel the cellular components that link cytokines and inflammation with hepatocarcinogenesis.
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HCC Risk in the Absence of Cirrhotic Liver Disease in Patients with NASH
September 12th 2016About one quarter of patients (26%) with nonalcoholic steatohepatitis (NASH)-associated hepatocellular carcinoma (HCC) present without cirrhosis at diagnosis, suggesting a crucial subset of patients for future research with implications for HCC screening and surveillance, according to Ju Dong Yang, MD, MSc, at the 10th Annual Conference of the International Liver Cancer Association (ILCA).
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Evidence Conflicting for Anti-HCV Drugs in Liver Cancer
September 12th 2016Though a new generation of drugs has proved highly effective against the hepatitis C virus (HCV), a leading risk factor for liver cancer in the United States, there is conflicting evidence about whether the therapies promote cancer recurrence in infected patients with hepatocellular carcinoma (HCC) who already have responded to curative treatment.
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The Significance of the RESORCE Trial in HCC
August 1st 2016Bruno Daniele, MD, director, Department of Oncology and Medical Oncology, G. Rummo Hospital, Italy, discusses the significance of the RESORCE trial, which examined the use of regorafenib (Stivarga) as a treatment for patients with hepatocellular carcinoma (HCC).
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