HEMATOLOGY

In an interview with Targeted Oncology, Zahra Mahmoudjafari, PharmD, BCOP, discussed the post hoc analysis from the REACH2 trial and highlighted the key takeaways.

A thorough review of promising therapies currently under investigation for the treatment of myelofibrosis.

An expert oncologist overviews quality-of-life data and considerations in treatment sequencing in myelofibrosis.

Research shows a high occurrence of ibrutinib-related cardiotoxicity in patients with cancer. This is the first study showing such evidence.

During a Targeted Oncology™ Case-Based Roundtable™ event, Noah M. Merin, MD, PhD, discussed biologic phases of chronic graft-vs-host disease and which therapies are available for patients who do not respond to steroids.

At 1 year, the GVHD-and–relapse-free survival achieved with Orca-Q was 75%, which was noted to compare favorably with prior data reported in context of myeloablative conditioning , haploidentical stem cell transplant, and posttransplant cyclophosphamide.

Ruxolitinib elicited higher responses at day 28 compared with best available therapy in most cytopenia-based subgroups and had durable responses at day 56, according to a post hoc analysis of the REACH2 trial.

According to findings presented at the 2023 Transplantation & Cellular Therapy Meetings, experts did not identify clear correlation between the pharmacokinetics and pharmacodynamics of ruxolitinib in patients with graft-vs-host-disease.

In 8 patients with various hematologic malignancies who received an allogeneic hematopoietic stem cell transplant with 7/8 non-permissive HLA mismatched donors, Orca-T led to a 100% survival rate.

The phase 3 REACH2 trial showed that early treatment with ruxolitinib 10 mg led to higher response rates vs that seen with the best available therapy in patients with grade II-IV steroid-refractory acute graft-vs-host disease.

Looking at a retrospective analysis of data from a single-center, the use of ruxolitinib decreased non-relapse mortality and improved overall survival for patients with steroid-refractory acute graft-vs-host-disease.

Final safety and efficacy read outs of the EQUATE trial show durable clinical responses and a favorable safety profile for acute graft-vs-host disease.

Aaron Gerds, MD, MS, discusses the MOMENTUM study and the potential role of momelotinib in the myelofibrosis treatment landscape.

A comprehensive overview of ruxolitinib, fedratinib, and pacritinib, the approved therapies for the treatment of myelofibrosis.

The phase 1/2 BRUIN study of pirtobrutinib led to promising early efficacy in patients with B-cell malignancies who were heavily pretreated with richter transformation.

Ben Derman, MD, discussed results from a trial investigating minimal residual disease–guided discontinuation of maintenance therapy in patients with multiple myeloma.

An expert on hematologic malignancies discusses the prognostic factors and molecular pathways involved in myelofibrosis.

Aaron Gerds, MD, MS, explains the types, presentations, and classic symptoms of myelofibrosis.

During a Targeted Oncology™ Case-Based Roundtable™ event, Javier Pinilla-Ibarz, MD, PhD, discussed risk factors and treatment options for tumor lysis syndrome.

Expert hematologist, Stephen Oh, MD, PhD, talks about unmet needs and promising new therapies in myelofibrosis.

Stephen Oh, MD, PhD, describes the factors that influence treatment selection in myelofibrosis, and then reviews sequencing strategies.

An overview of momelotinib, which was recently submitted for FDA approval, and how myelofibrosis treatments affect quality of life.

Stephen Oh, MD, PhD, gives a comprehensive review of the available treatment options for myelofibrosis.

An expert hematologist discusses important molecular targets in myelofibrosis, and when to consider transplant.

New research of the BTK degrader NX-2127 shows promising results for breaking down resistance to the therapy in the lymphoma and leukemia settings.