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Study data reported at the 2015 ASCO Annual Meeting has demonstrated a nearly 20% response rate with the anti-programmed cell death-1 (PD-1) monoclonal antibody nivolumab (Opdivo) in patients with HCC.

The small molecule multikinase inhibitor sorafenib remains the only molecularly targeted therapy approved by the FDA for the treatment of hepatocellular carcinoma, with ongoing clinical trials diligently testing the potential for novel targeted agents or combination therapies to further improve patient outcomes in this setting.