October 16th 2024
During a Case-Based Roundtable® event, Jennifer L. Atlas, MD, discussed treatment for a patient with basal cell carcinoma who reported challenging adverse events with hedgehog pathway inhibitor.
Advances in TNBC: Communicating with Your Patients About Clinical Trial Awareness and Treatment Concerns to Improve Clinical Outcomes
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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Fighting Disparities and Saving Lives: An Exploration of Challenges and Solutions in Cancer Care
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Older Age Correlates With Better Response to Anti-PD-1 Therapy in Melanoma
July 18th 2018Patients aged ≥62 years with melanoma were more likely to respond to treatment with pembrolizumab than younger patients, according to results published in <em>Clinical Cancer Research. </em>Investigators at The Wistar Institute in Philadelphia concluded that the risk for progression following anti–PD-1 therapy declined by 13% with each decade of life.
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Analysis Shows Incidence of Cardiovascular Toxicities Associated With ICIs
July 3rd 2018Immune checkpoint inhibitors, alone or in combination, are associated with increased incidence of some cardiovascular toxicities in patients with cancer, according to results from a cross-trial pooled analysis presented in a poster at the 2018 ASCO Annual Meeting.
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A Look Back at FDA News in June
July 2nd 2018The FDA approved several indications in the month of June, including venetoclax (Venclexta) in chronic lymphocytic leukemia (CLL) and small lymphocytic leukemia (SLL), the combination of binimetinib (Mektovi) plus encorafenib (Braftovi) in melanoma, and bevacizumab (Avastin) in ovarian cancer. The FDA also accelerated approvals for pembrolizumab (Keytruda) in cervical cancer and in primary mediastinal large B-cell lymphoma, while also granting a priority review to glasdegib for acute myeloid leukemia.
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Adjuvant Nivolumab Recommended for Approval by EU Panel
July 1st 2018Based on findings from the phase III CheckMate-238 trial, nivolumab (Opdivo) has been recommended for approval by the European Medicines Agency’s Committee for Medicinal Products for Human Use as an adjuvant treatment for adult patients with completely resected melanoma with lymph node involvement or metastatic disease, according to Bristol-Myers Squibb, the developer of the PD-1 inhibitor.
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Binimetinib/Encorafenib Combo Approved by FDA for BRAF+ Melanoma
June 27th 2018The combination of the BRAF inhibitor encorafenib (Braftovi) and the MEK inhibitor binimetinib (Mektovi) has been approved by the FDA for the treatment of patients with<em> BRAF</em>-mutant unresectable or metastatic melanoma, as detected by an FDA-approved test. The approval is based data from the phase III COLUMBUS trial.
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Application for Adjuvant Pembrolizumab in Stage III Melanoma Accepted by FDA
June 25th 2018A supplemental biologics license application for the use of pembrolizumab as an adjuvant treatment for patients with resected, high-risk stage III melanoma has been accepted by the FDA, according to Merck, the manufacturer of the PD-1 inhibitor.
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Pembrolizumab Survival Benefit in Melanoma Sustained at 4 Years
June 19th 2018Pembrolizumab (Keytruda) induced a median overall survival (OS) of 32.7 months versus 15.9 months for ipilimumab (Yervoy) in patients with unresectable stage III-IV melanoma, according to 4-year survival results from the KEYNOTE-006 trial presented at the 2018 ASCO Annual Meeting.
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Looking Back on the First Immune Checkpoint Inhibitor Approved in Melanoma
June 19th 2018Alexander M. Eggermont, MD, PhD, director general of Gustave Roussy Cancer Campus Grand Paris in Villejuif, France, discusses the history of immune checkpoint inhibitors in the treatment landscape of melanoma.
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Research Shows Growing Attention Toward Gut Microbiome's Role in Immunotherapy Response
June 18th 2018Researchers’ understanding of why patients with cancer do or do not respond to treatment with immune checkpoint inhibition is constantly evolving, with new developments in innate and adaptive immunity, the tumor microenvironment, and more changing the way that immunotherapy is viewed and used. Many researchers are now pointing to the effect that gut microbiota have on patients’ response to checkpoint inhibitors and its implications for the treatment of patients receiving immunotherapy.
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